吴川六
吴川六

个人简历:

教授:厦门大学 化学化工学院 化学系 (2014-)

副教授:厦门大学 化学化工学院 化学系 (2012-2013)

博士后(ETH Fellow):瑞士联邦理工学院(ETH Zurich),化学与应用生物学系,(2010-2012)

研究助理:新加坡国立大学 化学系(2008-2009)

本科、博士:厦门大学 化学系(2001-2005、2005-2010)

研究方向:

本课题组主要开展化学、材料、药学以及生物医学等领域的交叉课题研究,致力于解决生物医学等前沿领域所面临的基础化学难题。

研究方向主要包括:1)发展高质量的多肽分子(荧光)探针,研究蛋白质分子的功能;2)以荧光分子探针为工具,研究肿瘤细胞表面的化学性质(如氧化还原性质等);3)基于细胞内外微环境差异,构建响应型的分子递送系统,提高多肽等分子探针或药物分子的进细胞效率; 4)开展蛋白质分子相互作用识别机制研究,为发展高质量的多肽分子探针提供理论指导。

近期主要论文目录:

  1. “The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides”, Y. Chen, C. Yang, T. Li, M. Zhang, Y. Liu, M.A. Gauthier, Y. Zhao, and C. Wu*, Biomacromolecules, 2015, 16, 2347-2355.
  2. “Extraordinary Modulation of Disulfide Redox-Responsiveness by Cooperativity of Twin-Disulfide Bonds”, L. Zhai, J. Liang, X. Guo, Y. Zhao, and C. Wu*, Chem. Eur. J., 2014, 20, 17507-17514.
  3. “Exploring and Exploiting Dynamic Noncovalent Chemistry for Effective Surface Modification of Nanoscale Metal–Organic Frameworks”, S. Liu, L. Zhai, C. Li, Y. Li, X. Guo, Y. Zhao, and C. Wu*, ACS Appl. Mater. Interfaces, 2014, 6, 5404-5412.
  4. “Broad Control of Disulfide Stability through Microenvironmental Effects and Analysis in Complex Redox Environment”, C. Wu, S. Wang, L. Brulisauer, J-C. Leroux*, and M.A. Gauthier*, Biomacromolecules, 2013, 14, 2383-2388.
  5. “Twin Disulfides for Orthogonal Disulfide Pairing and the Directed Folding of Multicyclic Peptides”, C. Wu, J-C. Leroux*, and M.A. Gauthier*, Nature Chem., 2012, 4, 1044-1049.
  6. “Interplay of Chemical Micro-Environment and Redox Environment on Thiol-Disulfide Exchange Kinetics”, C. Wu, C. Belenda, J-C. Leroux, and M.A. Gauthier*, Chem. Eur. J., 2011, 17, 10064-10070.
  7. “Stable and Functionable Mesoporous Silica-Coated Gold Nanorods as Sensitive Localized Surface Plasmon Resonance (LSPR) Nanosensors”, C. Wu and Q.H. Xu*, Langmuir, 2009, 25, 9441-9446.
  8. “Molecule-Scale Controlled-Release System Based on Light-Responsive Silica Nanoparticles”, C. Wu, C. Chen, J. Lai, J. Chen, X. Mu, J. Zheng and Y. Zhao*, Chem. Commun., 2008, 2662-2664.
  9. “Fluorescent Core-Shell Silica Nanoparticles as Tunable Precursors: Towards Encoding and Multifunctional Nano-Probes”, C. Wu, J. Hong, X. Guo, C. Huang, J. Lai, J. Zheng, J. Chen, X. Mu and Y. Zhao*, Chem. Commun., 2008, 750-752.
  10. “Hybrid Silica-Nanocrystal-Organic Dye Superstructures as Post-encoding Fluorescent Probes”, C. Wu, J. Zheng, C. Huang, J. Lai, S. Li, C. Chen and Y. Zhao*, Angew. Chem. Int. Ed., 2007, 46, 5393-5396.

联系方式:

361005 厦门大学化学化工学院化学系 吴川六 教授
E-mail: chlwu@xmu.edu.cn