高锦豪
高锦豪

简历:

  • 学士(南京大学 2004)
  • 博士(香港科技大学 2008)
  • 博士后(斯坦福大学 2010)
  • 教授(厦门大学 2010.6-)

香港青年科学家奖(2007),教育部“新世纪优秀人才支持计划”(2010),福建省“闽江学者”特聘教授(2011),国家基金委优秀青年科学基金项目资助(2012),福建省杰出青年科学基金资助(2012),福建省青年拔尖创新人才(2014),中国化学会青年化学奖(2014)

研究兴趣:

  • 功能分子和纳米颗粒的设计合成及其生物医学应用研究:生物探针,致病菌检测,细胞自噬,体外诊断,分子影像及肿瘤成像诊断,药物输送,癌症治疗。


代表性论文:

  1. Zhou, Z. J.; Wu, C. Q.; Liu, H. Y.; Zhu, X. L.; Zhao, Z. H.; Wang, L. R.;  Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

  2. Zhao, Z. H.; Wang, X. M.; Zhang, Z. J.; Zhang, H.; Liu, H. Y.; Zhu, X. L.; Li, H.; Chi, X. Q.; Yin, Z. Y.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging. ACS Nano 2015, 9, 2749-2759.

  3. Zhu, X. L.; Hu, J; Zhao, Z. H.; Sun, M. J.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Kinetic and Sensitive Analysis of Tyrosinase Activity Using Electron Transfer Complexes: In Vitro and Intracellular Study. Small 2015, 11, 862-870.

  4. Wang, L. R.; Zhu, X. L.; Tang, X. Y.; Wu, C. Q.; Zhou, Z. J.; Sun, C. J.; Deng, S. L.; Ai, H.;  Gao, J. H.* A Multiple Gadolinium Complexes Decorated Fullerene as a Highly Sensitive T1 Contrast Agent. Chem. Commun. 2015, 51, 4390-4393.

  5. Huang, G. M.; Zhu, X. L.; Li, H; Wang, L. R.; Chi, X. Q.; Chen, J. H.; Wang, X. M.; Chen, Z.; Gao, J. H.* Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy. Nanoscale 2015, 7, 2667-2675.

  6. Zhou, Z. J.; Zhao, Z. H.; Zhang, H.; Wang, Z. Y.;  Chen, X. Y.; Wang, R. F.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

  7. Huang, G. M.; Li, H; Chen, J. H.; Zhao, Z. H.; Yang, L. J.; Chi, X. Q.; Chen, Z.; Wang, X. M.; Gao, J. H.* Tunable T1 and T2 Contrast Abilities of Manganese-engineered Iron Oxide Nanoparticles through Size Control. Nanoscale 2014, 6, 10404-10412.

  8. Huang, G. M.; Hu, J; Zhang, H.; Zhou, Z. J.; Chi, X. Q.; Gao, J. H.* Highly Magnetic Iron Carbide Nanoparticles as Effective T2 Contrast Agents. Nanoscale 2014, 6, 726-730.

  9. Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z.; Hu, J.; Chi, X.; Ni, K.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-performance T2 Contrast Agents for Magnetic Resonance Imaging. Nature Commun. 2013, 4, 2266.

  10. Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhan, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-oxide-based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.

  11. Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.

  12. Zhao, Z. H.; Huang, D. T.; Yin, Z. Y.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Magnetite Nanoparticles as Smart Carriers to Manipulate the Cytotoxicity of Anticancer Drugs: Magnetic Control and pH-Responsive Release. J. Mater. Chem. 2012, 22, 15717-15725.

  13. Chi, X. Q.; Huang, D.T.; Zhao, Z. H.; Zhou, Z. J.; Yin, Z. Y.; Gao, J. H.* Nanoprobes for In Vitro Diagnostics of Cancer and Infectious Diseases. Biomaterials 2012, 33, 189-206.

  14. Wei, Z. H.; Zhou, Z. J.;Yang, M.; Lin, C. H.; Zhao, Z. H.; Huang, D. T.; Chen, Z.; Gao, J. H.* Multifunctional Ag@Fe2O3 Yolk-shell Nanoparticles for Simultaneous Capture, Kill, and Removal of Pathogen. J. Mater. Chem. 2011, 21, 16344-16348.

  15. Gao, J. H.; Chen, K.; Luong, R.; Bouley, D. M.; Mao, H.; Qiao, T.; Gambhir, S. S.; Cheng, Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Lett. 2012, 12, 281-286.

  16. Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.

  17. Gao, J. H.; Xu, B.* Applications of Nanomaterials Inside Cells. Nano Today 2009, 4, 37-51.

  18. Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.

  19. Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.

  20. Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.

  21. Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.

  22. Gao, J. H.; Li, L. H.; Ho, P. L.; Mak, G. C.; Gu, H. W.; Xu, B.* Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood. Adv. Mater. 2006, 18, 3145-3148.

  23. Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.* Magnetic Dipolar Interaction Induced Self-Assembly Affords Wires of Cobalt Selenide Hollow Nanoscrystals. Angew. Chem. Int. Ed. 2006, 45, 1220-1223.

联系方式:

361005 厦门大学化学化工学院化学生物学系 高锦豪 教授
电话:0592-2180278
传真:0592-2189959
E-mail: jhgao@xmu.edu.cn