林东海
林东海

简历:

  • 博士 (厦门大学化学系,1989-1993);
  • 硕士 (厦门大学物理系,1986-1989);
  • 学士 (厦门大学物理系,1980-1984).
  • 博士后 (中国科学院武汉物理研究所,1993-1995);
  • 博士后 (美国City of Hope National Medical Center, 1998-2001);
  • 研究助理 (香港科技大学生物化学系,生物核磁共振中心, 2001-2003).


入选中国科学院“百人计划”;
入选上海市优秀学科带头人计划(A类);
厦门大学“闽江学者”特聘教授.
荣获2006度中国“王天眷”波谱学奖.
先后主持6项国家自然科学基金面上和重点项目.

研究兴趣:

  • 利用生物核磁共振等生物物理和分析化学技术开展结构生物学和代谢组学研究,包括:(1) 测定蛋白质、多肽及其复合物的溶液结构或晶体结构;(2) 研究蛋白质、多肽与配体的相互作用;(3) 测定蛋白质的动力学;(4) 基于结构的药物筛选:(5) 重大疾病的代谢特征和早期诊断方法以及术后检测方法;(6) 药物的药效和毒性评估以及代谢调控通路和作用机制的阐述,等等。

代表性论文:

  1. “Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel”,  Zongyun Chen, Youtian Hu, Jing Hu, Jun Hu, Weishan Yang, Fang Xiang, Zili Xie, Zhijian Cao, Wenxin Li, Donghai Lin*, Yingliang Wu*, Sci. Rep., 2015, 5: 9881, DOI: 10.1038/srep09881.
  2. “Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide”, Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*, Mol. Microbiol., 2015, 95 (5): 971-803.
  3. “Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy”, Wei Shao, Jinping Gu, Caihuang Huang, Dan Liu, Huiying Huang, Zicheng Huang, Zhen Lin, Wensheng Yang, Kun Liu, Donghai Lin*, Tianhai Ji*, Mol. Cancer., 2014, 13(1): 197-208.
  4. Heguo Yu, Jing Dong, Yihua Gu, Haiyan Liu, Aijie Xin, Huijuan Shi, Fei Sun, Yonglian Zhang, Donghai Lin*, Hua Diao*, J. Biol. Chem., 2013, 288 (17): 12270-12282.
  5. “The novel human beta-defensin 114 regulates lipopolysaccharide(LPS) -mediated inflammation and protects sperm from motility loss”, Heguo Yu, Jing Dong, Yihua Gu, Haiyan Liu, Aijie Xin, Huijuan Shi, Fei Sun, Yonglian Zhang, Donghai Lin*, Hua Diao*, J. Biol. Chem., 2013, 288 (17): 12270-12282.
  6. “Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory Peptide”,Lin Wei, Juanjuan Yang, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan, Donghai Lin*, Ren Lai*, J. Med. Chem., 2013, 56, 3546-3556.
  7. “Solution structural analysis of the single-domain parvulin TbPin1”, Lifang Sun, Xueji Wu, Yu Peng, Jianyuan Goh, Yihcherng Liou, Donghai Lin*, Yufen Zhao*, PLoS One, 2012, 7, e43017.
  8. “Metabonomic analysis of the therapeutic effect of Zhibai Dihuang Pill in treatment of streptozotocin-induced diabetic nephropathy”, Liangcai Zhao, Hongchang Gao, Yongxiang Zhao, Donghai Lin*, J. Ethnopharmacol., 2012, 142, 647-656.
  9. 1H NMR-based metabonomics in the kidneys provides new insight into pathophysiological mechanisms: applications for treatment with Cordyceps sinensis“, Fang Zhong, Xia Liu, Qiao Zhou, Xu Hao, Ying Lu, Shanmai Guo, Weiming Wang*, Donghai Lin*, Nan Chen, Nephrol. Dial. Transplant., 2012, 27, 556-565.
  10. 1H NMR-based metabolomic analysis of triptolide-Induced toxicity in liver-specific cytochrome P450 reductase knockout mice“,Xia Liu, Xiang Xue, Likun Gong, Xinming Qi, Yuanfeng Wu, Guozhen Xing, Yang Luan, Ying Xiao, Xiongfei Wu, Yan Li, Min Chen, Lingling Miao, Jun Yao, Jun Gu, Donghai Lin*, Jin Ren*, Metabolomics, 2012, 8, 907-918.

联系方式:

361005 厦门大学化学化工学院化学生物学系 林东海 教授
电话/传真:0592-2186078
E-mail: dhlin@xmu.edu.cn