林东海
林东海

简历:

  • 博士 (厦门大学化学系,1989-1993);
  • 硕士 (厦门大学物理系,1986-1989);
  • 学士 (厦门大学物理系,1980-1984).
  • 博士后 (中国科学院武汉物理研究所,1993-1995);
  • 博士后 (美国City of Hope National Medical Center, 1998-2001);
  • 研究助理 (香港科技大学生物化学系,生物核磁共振中心, 2001-2003).


入选中国科学院“百人计划”;
入选上海市优秀学科带头人计划(A类);
厦门大学“闽江学者”特聘教授.
荣获2006度中国“王天眷”波谱学奖.
先后主持6项国家自然科学基金面上和重点项目.

研究兴趣:

  • 主要利用生物核磁共振技术开展结构生物学研究和代谢组学研究, 包括:(I) 测定蛋白质、多肽及其与配体复合物的溶液结构;(II) 研究蛋白质、多肽与配体的相互作用;(III) 测定蛋白质的动力学;(IV) 研究重大疾病的代谢特征、生物标志物和早期诊断方法;(V) 研究药物的药效、毒性和作用机制。

代表性论文:

  1. “Characterization of the oligomerization and ligand-binding properties of recombinant rat lipocalin 11”, Y. Gu, Q. Liu, P. Chen, C. Guo, Y. Liu, Y. Zhao, Y. Zhao, D. Lin*, BBA – Proteins and Proteomics 2012, in press.
  2. “Solution structural analysis of the single-domain parvulin TbPin1”,L. Sun, X. Wu, Y. Peng, J.Y. Goh, Y.-C. Liou, D. Lin*, PLoS ONE 2012,7:e43017-e43017.
  3. “Metabonomic analysis of the therapeutic effect of Zhibai Dihuang Pill in treatment of streptozotocin-induced diabetic nephropathy”, L. Zhao, H. Gao, Y. Zhao, D. Lin*, J. Ethnopharmacol 2012, 142(3): 647-656.
  4. “1H NMR-based metabonomics in the kidneys provides new insight into pathophysiological mechanisms: applications for treatment with Cordyceps sinensis“, F. Zhong, X. Liu, Q. Zhou, X. Hao, Y. Lu, S. Guo, W. Wang*, D. Lin*, Nan Chen, Nephrology Dialysis Transplantation 2012,27 (2): 556-565.
  5. “1H NMR-based metabolomic analysis of triptolide-Induced toxicity in liver-specific cytochrome P450 reductase knockout mice“,X. Liu, X. Xue, L. Gong, X. Qi, Y. Wu, G. Xing, Y. Luan, Y. Xiao, X. Wu, Y. Li, M. Chen,D. Lin*,J. Ren*, Metabolomics 2011,Dec 4, DOI 10.1007/s11306-011-0385-1.
  6. “1H NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotoci“, L. Zhao, H. Gao, F. Lian, X. Liu, Y. Zhao, D. Lin*, Am J Physiol Renal Physiol 2011,300 (4): F947-956.
  7. “Unique structural characteristics of the rabbit prion protein”, Y. Wen, J. Li, W. Yao, M. Xiong, J. Hong, Y. Peng, G. Xiao, D. Lin*, J. Biol. Chem. 2010, 285, 31682-31693.
  8. “Frog skins keep redox homeostasis by antioxidant peptides with rapid radical-scavenging ability”, C. Liu, J. Hong, H. Yang, J. Wu, D. Ma, D. Lin*, R. Lai*, Free Radic Biol. Med. 2010, 48, 1173-1181.
  9. “Solution Structure and Dynamics of the I214V mutant of the Rabbit Prion Protein”, Y. Wen, J. Li, M. Xiong, Y. Peng, W. Yao, J. Hong, D. Lin*, PLoS ONE 2010, 5, e13202.
  10. “Structural Transformation of the Tandem Ubiquitin-Interacting Motifs in Ataxin-3 and Their Cooperative Interactions with Ubiquitin Chains”, A. Song, C. Zhou, Y. Peng, X. Gao, Z. Zhou, Q. Fu, J. Hong, D. Lin*, H. Hu*, PLoS ONE 2010, 5, e13273.

联系方式:

361005 厦门大学化学化工学院化学生物学系 林东海 教授
电话/传真:0592-2186078
E-mail: dhlin@xmu.edu.cn