杨朝勇
杨朝勇


教授、博士生导师

电话:(0592)2187621 (实验室)

          (0592)2187601 (办公室)

传真:(0592)2189959

电子邮箱:cyyang@xmu.edu.cn

课题组网页:http://www.yang-lab.com/


个人简历:
  学士(厦门大学,1998)
  硕士(厦门大学,2001)
  博士(美国佛罗里达大学,2006) 
  博士后(美国加州大学伯克利分校,2006-2007)
  教授(厦门大学,2008)


  担任 BMC Biochemistry 副主编、英国皇家化学会期刊 Analyst 国际顾问编委、美国物理联合会期刊 Biomicrofluidics 顾问编委、《分析化学》编委。
  先后主持973计划课题、国家自然科学基金等项目10余项。在PNAS, Angew. Chem. Int. Ed., J. Am. Chem. Soc., Anal. Chem.等国际顶级学术刊物发表论文120余篇,他引4000多次。获授权发明专利19项。编写英文专著1部。应邀在国际国内大型学术会议上做大会报告和特邀报告70余次。先后获美国化学会分析化学研究生奖、中国政府优秀自费留学生奖、中美化学与化学生物学教授协会杰出教授奖、国家杰出青年科学基金、中国青年分析化学家奖、中国化学会-英国皇家化学会青年化学奖、科技部中青年科技创新领军人才等奖项与称号。

研究兴趣:
  体外诊断新方法、微流控技术在生物医学中的应用、单细胞分析、纳米生物医学工程、功能核酸探针等。

近期主要代表论著:

  1.  Li, X; An, Y; Jin, J; Zhu, Z; Hao, L; Liu, L, Shi, Y; Fang, D, Ji, T; Yang, C*, Evolution of DNA Aptamers through in vitro Metastatic-cell-based SELEX for Metastatic Cancer Recognition and Imaging, Anal Chem, 2015, 87(9):4941-4948
  2. Xu L, Lei Z, Li J, Zong C, Yang C, Ren B*. Label-free Surface-enhanced Raman Spectroscopy Detection of DNA with Single-base Sensitivity, J. Am. Chem. Soc., 2015, 137(15):5149-54.
  3. Wei X, Tian T, Jia S, Zhu Z, Ma Y, Sun J, Lin Z*, Yang C*, Target-Responsive DNA Hydrogel Mediated “Stop-Flow” Microfluidic Paper-Based Analytic Device for Rapid,Portable and Visual Detection of Multiple Targets" Anal Chem. 2015, 87(8):4275-82
  4. Zhang H, Ma Y, Xie Y, An Y, Huang Y, Zhu Z, Yang C, A Controllable Aptamer-Based Self-Assembled DNA Dendrimer for High Affinity Targeting, Bioimaging and Drug Delivery, Scientific Reports, 2015, DOI: 10.1038/srep10099
  5. Lin Y, Liu Y, Fan C, Zheng H, Li Y, Zhang C, Wu S, Yu D, Huang Z, Liu F, Luo Q, Yang C, Ouyang G, MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1, Scientific Reports, 2015, DOI: 10.1038/srep09995
  6. Pu Y, Liu Z, Lu Y, Yuan P, Liu J, Yu B, Wang G, Yang C, Liu H, Tan W, Using DNA aptamer probe for immunostaining of cancer frozen tissues, Anal Chem. 2015, 87, 1919-1924
  7. Liu R, Huang Y, Ma Y, Jia S, Gao M, Li J, Zhang H, Xu D, Wu M, Chen Y, Zhu Z*, Yang C*, Design and Synthesis of Target-Responsive Aptamer-Crosslinked Hydrogel for Visual Quantitative Detection of Ochratoxin A, ACS Applied Materials & Interfaces. 2015, 7(12), 6982-9
  8.  Xie, Y.; Lin, X.; Huang, Y.; Pan, R.; Zhu, Z.; Zhou, L. *; Yang, C. * , Highly Sensitive and Selective Detection of miRNA: DNase I-Assisted Target Recycling using DNA Probes Protected by Polydopamine Nanospheres, Chem Commun, 2015, 51, 2156-2158
  9. Huang, Y; Ma, Y; Chen, Y; Wu, X; Fang, L; Zhu, Z; Yang, C*, Target-Responsive DNAzyme Crosslinked Hydrogel for Visual Quantitative Detection of Lead, Anal Chem, 2014, 86, DOI: 10.1021/ac503540q
  10. Ke, G; Zhu, Z*; Wang, W; Zou, Y; Guan, Z; Jia S; Zhang, H; Wu, X; Yang, C*; A Cell Surface-Anchored Ratiometric Fluorescent Probe for Extracellular pH Sensing, ACS Applied Materials & Interfaces, 2014, DOI: 10.1021/am503818n.
  11. Zhu Z; Guan, Z; Jia S;Lei Z; Lin, S; Zhang, H; Ma, Y; Tian, Z; Yang, C*; Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing,Angew. Chem. Int. Ed. Engl. 2014,53, 12503-12507
  12.  Tan, J; Ding L; Ju H*; Yang Y; Li X; Shen Z; Zhu Z; Yu J*Yang C*; A Multifunctional Nanomicelle for Real-Time Targeted Imaging and Precise Near-Infrared Therapy of Cancer, Angew. Chem. Int. Ed. Engl. 2014, 53, 9544-9549
  13. Cai, Z; Chen, Y; Lin C; Wu, Y; Yang, C*; Wang, Y; Chen, X*; A Dual-Signal Amplification Method for the DNA Detection Based on Exonuclease III, Biosensors and Bioelectronics2014, 60, 370-373                       
  14. Li  X; Zhang, W; Liu, L; Zhu, Z; Ouyang, G; An, Y; Zhao, C; Yang, C*, In Vitro Selection of DNA Aptamersfor Metastatic Breast Cancer Cell Recognition and Tissue Imaging, Anal Chem, 2014,86, 6596-6603
  15. Zhu,Z; Song, Y; Li C; Zou Y; Zhu L; An Y; Yang C*; Monoclonal Surface Display SELEX for Simple, Rapid, Efficient and Cost-Effective Aptamer Enrichment and Identification, Anal Chem, 201486, 5881-5888.
  16. Lin X; Cui L; Huang Y; Lin Y; Xie Y; Zhu, Z*; Chen X; Yang, C*; Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules Based on Nuclease-Assisted Target Recycling Signal Amplification, Chem Commun2014, 50, 7646-7648.
  17.  Zhang, H; Song, Y; Zou, Y; Ge, Y; An, Y; Ma, Y; Zhu, Z*; Yang, C*;  A Diazirine-Based Photoaffinity Probe for Facile and Efficient Aptamer-Protein Covalent Conjugation, Chem Commun 2014, 50 (38), 4891 – 4894.
  18. Guan, Z; Jia S; Zhu, Z; Zhang, M; Yang, C*, Facile and Rapid Generation of Large-scale Micro-collagen-gel Array for Long-term Single Cell 3D Culture and Cell Proliferation Heterogeneity Analysis, Anal Chem, 2014, 86, 2789-2797.
  19. Guan,Z; Zou, Y; Zhang, M; Lv J; Shen, H; Yang, P; Zhang, H; Zhu, Z; Yang, C*; A Highly Parallel Microfluidic Droplet Method Enabling Single-Molecule Counting for Digital Enzyme Detection, Biomicrofluidics2014 8(1),014110 . 
  20. Liu, D; Lin B; Shao, W; Zhu, Z; Ji, T*; Yang, C*, In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the BloodBrain Barrier, ACS Applied Materials & Interfaces, 2014,6, 2131–2136.
  21. Cui, L; Zhu, Z; Lin, L; Zhang, H; Guan, Z; Yang, C*, Exonuclease-Assisted Cyclic Enzymatic Amplification Method Coupled with Rolling Circle Amplification: A Dual-amplification Strategy for Sensitive and Selective MicroRNA Detection. Chem. Commun.2014, 50 (13), 1576 – 1578. 
  22. Luo, Y; Yan, X; Huang, Y; Wen, R; Li, Z; Yang, L; Yang, C; Wang, Q*, ICP-MS-Based Multiplex and Ultrasensitive Assay of Viruses with Lanthanide-Coded Biospecific Tagging and Amplification Strategies, Anal Chem, 2013, 85 (20), 9428–9432.
  23. Zou,Y; Chen,J;Zhu, Z; Lu,L;Huang,Y; Song,Y;Zhang,H;Kang,H;Yang,C,* Single-Molecule Photon-Fueled DNA Nanoscissors for DNA Cleavage based on the Regulation of Substrate Binding Affinity by Azobenzene, Chem. Commun.,2013, 49(77), 8716-8718. 
  24. Wu, C; Chen, T; Han, D; You, M; Peng, L; Cansiz, S; Zhu, G; Li, C; Xiong, X; Jimene, E; Yang, C; Tan, W*Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells, ACS Nano, 2013, 7(7), 5724-31.
  25. Cui, L; Ke, G; Lin, X; Song, Y; Zhang, H; Guan, Z; Zhu, Z*; Yang, C. “Cyclic Enzymatic Amplification Method (CEAM) Based on Exonuclease III for Highly Sensitive Bioanalysis.” Methods, 2013, 63(3), 202-211

  26. Lin, X; Zhang, C; Huang, Y; Zhu, Z*; Chen, X; Yang, C*; Backbone-Modified Molecular Beacons for Highly Sensitive and Selective Detection of MicroRNA Based on Duplex Specific Nuclease Signal Amplification, Chem. Commun.,2013, 49 (65), 7243 - 7245    
  27. Cui, L; Song, Y; Ke, G; Guan, Z; Zhang, H; Lin, Y; Huang, Y; Zhu, Z*; Yang, C*; Graphene Oxide-Protected Nucleic Acid Probes for Bioanalysis and Biomedicine, Chem.-Eur. J., 2013, 19 (32):10442-10451.  
  28. Song, Y; Zhu, Z; An, Y; Zhang, W; Zhang, H; Liu, D; Yu, C; Duan, W;Yang, C*; Selection of DNA Aptamers against Epithelial Cell AdhesionMolecule for Cancer Cell Imaging and Circulating Tumor Cell Capture,Anal Chem2013, 85 (8), 4141–4149    
  29. Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M;Zhou, Y; Zhou, S; Yang, C*, Target-repsonsive “Sweet” Hydrogel withGlucometer Readout: an Effective Method for Portable and QuantitativeDetection of Non-glucose Targets, J. Am. Chem. Soc., 2013, 135 (10),3748–3751 (Cover, Highlighted by JACS Spotlights) 
  30. Cui, L; Chen, Z; Zhu, Z; Xiaoyan Lin; Chen, X; Yang, C*,Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way toDesign Highly Robust RNA Probes, Anal Chem2013, 85 (4), 2269–2275.   
  31. Xiong, X; Liu, H; Zhao, Z; Altman, M; Lopez-Colon, D; Yang, C*,Chang, L; Liu, C; Tan, W*; DNA Aptamer-mediated Cell Targeting, Angew.Chem. Int. Ed Engl2013, 2013, 1472 –1476 
  32. Ke, G; Wang, C; Ge Y; Zheng, N; Zhu Z; Yang, C*, L-DNA Molecular Beacons: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells, J. Am. Chem. Soc., 2012, 134,18908-18911
  33. Zhu, L; Li, C; Zhu, Z; Zou, Y; Fu, H; Wang, C; Yang, C*, In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes, Anal Chem2012, 84(19):8383-8390
  34. Wu, J; Wang, C; Li, X; Song, Y; Wang, W; Li, C; Hu, J; Zhu Z*; Zhang, W; Lu Z*; Yang, C*, Identification, Characterization and Application of a G-quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2,PLoS ONE2012, 7(9): e46393
  35. Zhao, X; Wu, J; Liang, J; Yan, J; Zhu, Z; Yang, C*; Mao, B*, Single-Molecule Force Spectroscopic Studies on Intra- and Inter-Molecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein,J Physic Chem B2012, 116(37):11397-404
  36. Zhou, T; Huang, Y; Li W; Cai, Z; Luo F; Yang, C*; Chen X*, Facile synthesis of red-emitting lysozyme-stabilized Ag nanoclusters, Nanoscale 2012, 4, 5312–5315
  37. Kang, D*; Wang, J; Zhang, W; Zhu, M; Zhu, Z;; Yang, C*, Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity, PLoS ONE2012, 7(10): e42731
  38. Li, C; Zhu, L; Zhu, Z; Fu, H; Jenkins, G; Wang, C; Zou, Y; Lu, X; Yang, C*, Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme, Chem. Commun., 2012, 48 (67), 8347 - 8349
  39. Zhu, Z; Zhang, W; Leng, X; Zhang, M; Guan, Z, Yang, C*, Highly Sensitive and Quantitative Detection of Rare Pathogen through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level, Lab Chip 2012, 12 (20), 3907 - 3913.
  40. Cui, L; Zou, Y; Lin, N; Zhu, Z; Jenkins, G; Yang, C* , Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples, Anal Chem2012, 84 (13),5535-5541
  41. Zhang, H; Jenkins, G; Zou, Y; Zhu, Z; Yang, C* , Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics, Anal Chem2012, 84 (8), 3599–3606
  42. Zhu, Z; Jenkins, G; Zhang,W; Zhang M; Guan Z; Yang, C* ,Single-Molecule Emulsion PCR in Microfluidic Droplet, Anal Bioanal Chem2012, 403(8), 2127-2143
  43. Zhang, W; Zhang, W; Liu, Z; Li, C; Zhu, Z; Yang, C*, A Highly Parallel Single Molecule Amplification Approach Based on Agarose Droplet PCR for Efficient and Cost-effectiveAptamer Selection, Anal Chem,2012, 84 (1), 350–355
  44. Song, Y; Zhang, W; An, Y; Cui, L; Chen, X; Zhu, Z*; Yang, C*, Label-Free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability, Chem. Commun.,2012, 48, 576-578
  45. Cui, L; Lin, X; Lin, N; Song, Y; Zhu, Z; Yang, C*, Graphene Oxide -ProtectedDNA Probesfor Multiplex MicroRNA Analysis in Complex Biological Samples Based on Cyclic Enzymatic Amplification Method,Chem. Commun., 2012, 48, 194-196 (Inside Cover)
  46. Wang, X; Zhou, T, Song, X; Jiang, Y; Yang, C, Chen, X; Chameleon clothes for quantitative oxygen imaging, J. Mater. Chem., 2011, 21, 17651
  47. Shigdar, S;Ward, A; De, A; Yang, C; Wei, M; Duan, W, Clinical Applications of Aptamers and Nucleic Acid Therapeutics in Haematological Malignancies, British Journal of Haematology, 2011, 155,3-13
  48. Tan, W; Wang, H;Chen, Y; Zhang, X; Zhu, H; Yang, C; Yang, R., Molecular aptamers for drug delivery, Trends in Biotechnology, 2011,12, 634-640
  49. Yang, C. *; Cui, L.; Huang, J.;Yan, L.; Lin, X.; Wang, C.; Zhang, W.; Kang, H; Linear Molecular Beacons for Highly SensitiveBioanalysis Based on Cyclic Exo III EnzymaticAmplification,Biosensors and Bioelectronics, 2011, 29, 119-124
  50. Song, Y.; Cui, L.; Wu, J.;Zhang, W.; Kang, H.; Yang, C.*, Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins and Small Molecules in Complex Biological Samples,Chem.-Eur. J., 2011,17, 9042-9046(Inside Cover)
  51. Lin, H.; Zou, Y.; Huang, Y.; Chen, J.; Zhang, W.; Zhuang, Z.; Jenkins, G.; Yang, C. *; DNAzymeCrosslinkedHydrogel: ANew Platform for Visual Detection of Metal Ions,Chem. Commun., 2011, 47, 9312–9314.(Back Cover)
  52. Fang, X.; Cai, Y.; Liu, J.; Wang, Z.; Wu, Q.; Zhang, Z.; Yang, C.; Yuan, L.; Ouyang, G. *;Twist2 contributes to breast cancer progression by promoting anepithelial-mesenchymal transition and cancer stem-like cellself-renewal,Oncogene,2011,30(47):4707-20
  53. Wang, K.; You, M.; Chen, Y.; Han, D.; Zhu, Z. Huang, J.;Williams, K.; Yang, C. *; Tan, W. * ; Self-assembly of a Bifunctional DNA Carrier for DrugDelivery, Angew. Chem. Int. Ed Engl., 2011,50, 27,6098–6101
  54. Wang, X; Song, X.; He, C.; Yang, C. Chen, G.; Chen, X.; Preparation of Reversible Colorimetric Temperature Nanosensors andTheir Application in Quantitative Two-Dimensional Thermo-Imaging; Anal Chem., 2011, 83, 2434–2437
  55. Wang, C.; Zhu, Z.; Song, Y.; Lin H.; Yang C. *; Tan, W*;Caged molecular beacons: controlling nucleic acid hybridizationwith light, Chem. Commun.,2011,47 (20), 5708 - 5710
  56. Hu, J.; Wu,J.; Li,C.; Zhu, L.; Zhang,W.; Kong, G.; Lu Z. *; Yang, C. *; A G-quadruplexAptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2in vitro,ChemBioChem, 2011, 12, 424 – 430
  57. Cui, L.; Ke, G.; Zhang, W.; Yang, C. *; A Universal Platform for Sensitive and Selective Colorimetric DNA Detection Based on Exo III Assisted Signal Amplification, Biosensors and Bioelectronics, 2011,26, 2796–2800
  58. Huang, J.; Wu, Y.; Chen, Y.;, Zhu, Z.; Yang, X.; Yang, C.*; Wang, K.*; Tan, W.*; PyreneExcimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed Engl., 2011,50, 401-404
  59. Wang, C.; Wu ,C.; Chen, Y; Song, Y; Tan, W; Yang, C.*,PyreneExcimer for DNA Sensors, Current Organic Chemistry,2011, 15(4), 465-476
  60. Chen, Y.; O'Donoghue, M.; Huang, Y.; Kang, H.; Phillips, J.; Chen, X; Estevez, M.; Yang, C.; Tan, W. *,A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces, J. Am. Chem. Soc., 2010, 132 (46), 16559–16570
  61. Li, D.; Guan, Z.; Zhang, W.; Zhou X.; Zhuang, Z.; Wang, X. and Yang, C.* , Synthesis of Uniform-size Hollow Silica Microspheres through Interfacial Polymerization in Monodisperse Water-in-oil Droplets,ACSApplied Materials & Interfaces,2010, 2(10), 2711-2713
  62. Wu, C.; Hu, J.; Zou, Y. A.; Wang, C.; Liu, J.*; Yang, C.*. Application of Aptamers in Biomedicine. Progress in Chemistry,2010,22 (8), 1518-1530. (Invited Review)
  63. Ouyang, G.; Wang, Z.; Fang, X. and Yang, C.; Molecular Signaling of the Epithelial to Mesenchymal Transition in Generating and Maintaining Cancer Stem Cells, Cellular and Molecular Life Sciences2010, 67, 2605-2618
  64. Leng, X.; Zhang, W.; Wang, C.; Cui, L,; Yang, C. *, Agarose Droplet Microfluidics for Highly Parallel and EfficientSingle Molecule Emulsion PCR, Lab Chip, 2010,10(21),2841-2843. (Inside Cover),(Top Ten Accessed Paper, 2010 September)
  65. Cui, L.; Ke, G.; Wang, C.;Yang, C.*, A Cyclic Enzymatic Amplification Method for Sensitive and Selective Detection of Nucleic Acids, Analyst, 2010,135,2069-2073
  66. Wu ,C.; Yan, L.; Wang, C.; Wang, C.; Chen, X.; Yang, C.*,A General Excimer Signaling Approach for Aptamer Sensors,Biosensors and Bioelectronics, 2010, 25(10), 2232-2237.
  67. Zhu, Z.; Wu C.; Liu H.; Zou Y.; Zhang X.; Kang H.; Yang C.*; Tan W.*, Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed Engl, 2010,49(2)1052 –1056(Frontipiece Paper)
  68. Yang, C.; Tan, W.,Understanding Bioanalytical Chemistry: Principles and Applications. By Victor A. Gault and Neville H. McClenaghan. ChemBioChem, 2010, 11(3), 434.
  69. Wu ,C.; Wang, C.;Yan, L.; Wang, C.; Yang, C.*PyreneExcimer Nucleic Acid Probes forBiomolecule Signaling.J. of Biomed. Nanotech. 2009, 5.495–504
  70. Zhang, W.; Lin, S.; Wang, C.; Hu, J.; Li, C.; Zhuang, Z.; Zhou, Y.; Mathies, R. A.*; Yang, C.* PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip, 2009,9 (21), 3088-3094
  71. Wang, K.; Tang, Z.; Yang, C.; Kim, Y.; Fang, X.; Li, W.; Wu, Y.; Medley, C. D.; Cao, Z.; Li, J.; Colon, P.; Lin, H.; Tan, W. Molecular engineering of DNA: molecular beacons. Angew. Chem. Int. Ed Engl. , 2009,48 (5), 856-870.
  72. Martinez, K.; Medley, C. D.; Yang, C.; Tan, W. Investigation of the hybrid molecular probe for intracellular studies. Anal. Bioanal. Chem. , 2008,391 (3), 983-991.
  73. Kumaresan, P.; Yang, C.; Cronier, S. A.; Blazej, R. G.; Mathies, R. A. High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal. Chem.,??2008,80 (10), 3522-3529.(Cover)(First Coauthor)
  74. Wu, Y.; Yang, C.; Moroz, L. L.; Tan, W. Nucleic acid beacons for long-term real-time intracellular monitoring. Anal. Chem,2008,80 (8), 3025-3028.
  75. Chen, Y.; Yang, C.; Wu, Y.; Conlon, P.; Kim, Y.; Lin, H.; Tan, W. Light-switching excimer beacon assays for ribonuclease H kinetic study.Chembiochem, 2008,9 (3), 355-359.
  76. Conlon, P.; Yang, C.; Wu, Y.; Chen, Y.; Martinez, K.; Kim, Y.; Stevens, N.; Marti, A. A.; Jockusch, S.; Turro, N. J.; Tan, W. Pyrene excimer signaling molecular beacons for probing nucleic acids.J. Am. Chem. Soc. 2008,130 (1), 336-342.
  77. Kim, Y.; Yang, C.; Tan, W. Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem.Nucleic Acids Res., 2007,35 (21), 7279-7287.
  78. Yang, C.; Wang, L.; Wu, Y.; Kim, Y.; Medley, C. D.; Lin, H.; Tan, W. Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons. Nucleic Acids Res., 2007,35 (12), 4030-4041.
  79. Yang, C.; Martinez, K.; Lin, H.; Tan, W. Hybrid molecular probe for nucleic acid analysis in biological samples. J. Am. Chem. Soc. , 2006,128 (31), 9986-9987.
  80. Shangguan, D.; Li, Y.; Tang, Z.; Cao, Z. C.; Chen, H. W.; Mallikaratchy, P.; Sefah, K.; Yang, C.; Tan, W. Aptamers evolved from live cells as effective molecular probes for cancer study. Proc. Natl. Acad. Sci. U. S. A,2006,103 (32), 11838-11843.
  81. Yang, C.; Li, J. J.; Tan, W. Using molecular beacons for sensitive fluorescence assays of the enzymatic cleavage of nucleic acids.Methods Mol. Biol., 2006,335, 71-81.
  82. Liu, H.; Wang, H.; Shi, Z.; Wang, H.; Yang, C.; Silke, S.; Tan, W.; Lu, Z. TaqMan probe array for quantitative detection of DNA targets. Nucleic Acids Res. , 2006, 34 (1), Art. No. E4
  83. Tan, L.; Li, Y.; Drake, T.; Moroz, L.; Wang, K.; Li, J.; Munteanu, A.; Yang, C.; Martinez, K.; Tan, W. Molecular beacons for bioanalytical applications. Analyst,2005, 130 (7), 1002-1005.
  84. Yang, C.; Medley, C. D.; Tan, W. Monitoring nucleic acids using molecular beacons. Curr. Pharm. Biotechnol. , 2005,6 (6), 445-452.
  85. Yang, C.; Jockusch, S.; Vicens, M.; Turro, N. J.; Tan, W. Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc. Natl. Acad. Sci. U. S. A, 2005,102 (48), 17278-17283.
  86. Wang, L.; Yang, C.; Medley, C. D.; Benner, S. A.; Tan, W. Locked nucleic acid molecular beacons. J. Am. Chem. Soc. , 2005,127 (45), 15664-15665.
  87. Yang, C.; Lin, H.; Tan, W. Molecular assembly of superquenchers in signaling molecular interactions. J. Am. Chem. Soc.,2005,127 (37), 12772-12773.
  88. Yang, C.; Pinto, M.; Schanze, K.; Tan, W. Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio. Angew. Chem. Int. Ed Engl., ??2005,44 (17), 2572-2576.
  89. Bagwe, R. P.; Yang, C.; Hilliard, L. R.; Tan, W. Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir, 2004,20 (19), 8336-8342.
  90. Wang, L.; Yang, C.; Tan, W. Dual-luminophore-doped silica nanoparticles for multiplexed signaling. Nano Lett. , 2005,5 (1), 37-43.
  91. Huang, Z.; Yang, C.; Zhuang, Z.; Wang, X.; Lee, F. S. C. Determination of trace lead in the high salt matrix of comestible CaCO3 by an isotope dilution method with detection by inductively coupled plasma-mass spectrometry. Analytica Chimica Acta, 2004,509 (1), 77-82.