王秋泉
王秋泉

简介:

王秋泉 厦门大学特聘教授/博士生导师

1998年获日本群马大学工学博士学位。担任Anal. Sci.副主编(2010-2011)、Anal. Bioanal. Chem.国际顾问委员会委员、《环境化学》编委、《科学通报》编委、《分析化学》编委、中国仪器仪表学会原子光谱分析专业委员会副主任委员兼秘书长、中国稀土学会理化检验委员会委员。研究兴趣为色谱与分离科学和原子光谱/质谱分析,主要应用色谱/电泳-光谱/质谱联用技术开展复杂环境和生物体系中关键元素和分子的分析方法学、持久性有毒污染物质的分离和检测,关注相关的“迁移转化”、“生物可利用性/毒性”、“污染环境的生物修复机制”;发展化学选择性和生物专一性元素标记策略,开展金属组学和定量蛋白质组学研究。承担“973”、“863”、国家自然科学基金重点项目等课题的研究工作。在Angew. Chem. Int. Ed., Environ. Sci. & Technol., Metallomics, Anal. Chem., J. Anal. At. Spectrom., J. Chromatogr. A/B, J. Am. Soc. Mass Spectrom.等学术期刊上发表研究论文70余篇,参与Elsevier 编著1部,应邀在国际国内大型学术会议上做大会报告和特邀报告20余次。现任厦门大学化学化工学院化学系分析科学研究所所长。

研究兴趣:

  1. 原子光谱/质谱原子/离子化新原理新方法
  2. 新型色谱/电泳固定相的设计合成
  3. 色谱/电泳-光谱/质谱联用新技术新方法
  4. 环境生命体系中关键元素/分子的分析方法学
  5. 金属组学、代谢组学、定量蛋白质组学和细胞组学研究 

近期代表性论文:

  1. “Click Chemistry Mediated Eu-Tagging: Activity-Based Specific Quantification and Simultaneous Activity Evaluation of CYP3A4 Using Eu-153 Species-Unspecific Isotope Dilution Inductively Coupled Plasma Mass Spectrometry”, Y. Liang, X. W. Yan, Z. X. Li, L. M. Yang, B. Zhang, Q. Q. Wang, Anal. Chem. 2014, 86, 3688-3692
  2. “Evaluation of BDE-47 Hydroxylation Metabolic Pathways Based on a Strong Electron-Withdrawing Pentafluorobenzoyl Derivatization Gas Chromatography/Electron Capture Negative Ionization Quadrupole Mass Spectrometry”, C. Zhai, S. N. Peng, L. M. Yang, Q. Q. Wang, Environ. Sci. Technol. 2014, 48, 8117-8126
  3. “A chemical ''hub'' for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry”, X. W. Yan, Z. X. Li, Y. Liang, L. M. Yang, B. Zhang, Q. Q. Wang, Chem. Common. 2014, 50, 6578-6581
  4. “ICP-MS-Based Multiplex and Ultrasensitive Assay of Viruses with Lanthanide-Coded Biospecific Tagging and Amplification Strategies”, Yacui Luo, X. W. Yan, Y. S. Huang, R. B. Wen, Z. X. Li, L. M. Yang, C. Y. J. Yang, Q. Q. Wang, Anal. Chem. 2013, 85, 9428-9432
  5. “Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS”, M. Xu, L. M. Yang, Q. Q. Wang, Metallomics 2013, 5, 855-860
  6. “Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS”, X. W. Yan, Y. C. Luo, Z. B. Zhang, Z. X. Li, Q. Luo, L. M. Yang, B. Zhang, H. F. Chen, P. M. Bai, Q. Q. Wang, Angew. Chem. Int. Ed. 2012, 51, 3358-3363
  7. “Integrin-Targeted Trifunctional Probe for Cancer Cells: A ‘Seeing and Counting’ Approach, Z. B. Zhang, Q. Luo, X. W. Yan, Z. X. Li, Y. C. Luo, L. M. Yang, B. Zhang, H. F. Chen, Q. Q. Wang, Anal. Chem. 2012, 84, 8946-8951
  8. “Nanosemiconductor-based Photo-catalytic Vapor Generation Systems for Subsequent Selenium Determination and Speciation with Atomic Fluorescence Spectrometry and Inductively Coupled Plasma Mass Spectrometry”, H. M. Li, Y. C. Luo, Z. X. Li, L. M. Yang, Q. Q. Wang, Anal. Chem. 2012, 84, 2974-2981
  9. “A Way to Probe the Microenvironment of Free Sulfhydryls in Intact Proteins with a Series of Monofunctional Organic Mercurials”, M. Xu, L. M. Yang, Q. Q. Wang, Chem. Eur. J. 2012, 18, 13989-13993
  10. “Lanthanide-Coded Protease-Specific Peptide-Nanoparticle Probes for a Label-Free Multiplex Protease Assay Using Element Mass Spectrometry: A Proof-of-Concept Study”, Xiaowen Yan, Limin Yang, Qiuquan Wang, Angew. Chem. Int. Ed. 2011, 50, 5130-5133
  11. “Dynamic Labeling Strategy with 204Hg-Isotopic Methylmercurithiosalicylate for Absolute Peptide and Protein Quantification”, Ming Xu, Xiaowen Yan, Qingqing Xie, Limin Yang, Qiuquan Wang, Anal. Chem. 2010, 82, 1616-1620
  12. “Absolute Quantification of Intact Proteins via 1,4,7,10-Tetraazacyclododecane -1,4,7-trisacetic acid-10-Maleimidoethyl acetamide-Europium Labeling and HPLC Coupled with Species-Unspecific Isotope Dilution ICPMS”, X. W. Yan, M. Xu, L. M. Yang, Q. Q. Wang, Anal. Chem. 2010, 82, 1261-1269

联系方式:

361005 厦门大学化学化工学院化学系,分析科学研究所
电话:0592-218 1796(实验室)

传真:0592-218 7400(实验室)
E-mail: qqwang@xmu.edu.cn
实验室主页:http://ias.xmu.edu.cn/wangqiuquan/